Merlin anticorps (AA 516-520)

N° du produit ABIN362948

Cet anticorps Lapin Polyclonal détecte spécifiquement Merlin dans WB et IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Merlin anticorps (AA 516-520) (ABIN362948)

Antigène: Merlin (NF2) (Neurofibromin 2 (NF2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Merlin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Merlin anticorps

Épitope: AA 516-520

Specificité: The antibody detects endogenous level of total Merlin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Peptide sequence around AA 516-520 (R-L-S-M-E) derived from Human Merlin. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur Merlin

Antigène: Merlin (NF2) (Neurofibromin 2 (NF2))

Autre désignation: Merlin

Sujet: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity.

Poids moléculaire: 69 kDa

NCBI Accession: NP_000259

UniProt: P35240

Pathways: Cell-Cell Junction Organization